Related Experiment Videos
Mutagenicity studies on thymomodulin
G Cantelli-Forti1, P Hrelia, M Scotti
1Institute of Pharmacology, University of Bologna, Italy.
Arzneimittel-Forschung
|November 1, 1987
Summary
Thymomodulin (Leucotrofina), a thymic derivative, was evaluated for its potential to cause genetic mutations. Multiple in vitro and in vivo tests confirmed that thymomodulin is not mutagenic.
Area of Science:
- Pharmacology
- Toxicology
- Immunology
Background:
- Thymomodulin (Leucotrofina) is an orally administered thymic derivative.
- It exhibits immunomodulating and myelomodulating properties.
Purpose of the Study:
- To assess the mutagenic potential of Thymomodulin (Leucotrofina).
Main Methods:
- In vitro tests: bacterial mutagenesis (S. typhimurium), yeast gene conversion (S. cerevisiae D7), DNA repair.
- In vivo tests: host-mediated assay in mice, urinary assay in mice.
Main Results:
- Thymomodulin did not induce mutations in S. typhimurium.
- No gene conversion was observed in S. cerevisiae D7.
- In vivo assays in mice showed no evidence of mutagenicity.
Conclusions:
- Thymomodulin is devoid of mutagenic activity.
- The compound is safe regarding genotoxicity based on the conducted tests.