Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifunctional Hydrogel-Based Scaffolds: Integrating Conductive Nanomaterials for Smart Wound Healing Applications.

Gels (Basel, Switzerland)·2026
Same author

Bioinspired 3D Printing of Lignocellulose-Based Multimaterial Composites for Extracellular Matrix-Mimicking Architectures.

Biomimetics (Basel, Switzerland)·2026
Same author

A Biomimetic Microfluidic Triple-compartment Periodontium-on-chip for Investigation of Inflammatory Responses in Periodontitis.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

ZnO-Hydroxyapatite-Coated Ti-6Al-4V With Curcumin and Ginger Extract for Load-Bearing Implants.

Journal of the American Ceramic Society. American Ceramic Society·2026
Same author

3D-Printed Piezoionic/Bioelectronic Hydrogel for Electro-Metabolic Regulation of Osteogenic Differentiation.

Advanced healthcare materials·2026
Same author

Polydopamine-based Surface Modifications for Tissue Engineering and Biosensing: From Understanding Chemistry to Diverse Applications.

JOM (Warrendale, Pa. : 1989)·2026

Related Experiment Video

Updated: Nov 27, 2025

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.2K

Human Teeth-Derived Bioceramics for Improved Bone Regeneration.

Ki-Taek Lim1, Dinesh K Patel1, Sayan Deb Dutta1

  • 1Department of Biosystems Engineering, Kangwon National University, Chuncheon 24341, Korea.

Nanomaterials (Basel, Switzerland)
|December 3, 2020
PubMed
Summary

Human teeth-derived bioceramics show potential for bone regeneration. These biocompatible materials enhanced bone repair and vascularization in mice, offering a promising alternative for bone tissue engineering applications.

Keywords:
bioceramicsbiocompatibilitybone regenerationhuman tooth powdervascularization

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.1K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.3K

Related Experiment Videos

Last Updated: Nov 27, 2025

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.2K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.1K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.3K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Ceramics Engineering

Background:

  • Hydroxyapatite (HAp) is ideal for bone regeneration due to its similarity to human hard tissues.
  • Synthetic HAp faces limitations in purity and production techniques for bone tissue engineering.
  • Human teeth offer a viable source for HAp-derived bioceramics.

Purpose of the Study:

  • To develop and assess bone regeneration potential of human teeth-derived bioceramics.
  • To evaluate the biocompatibility and efficacy of these bioceramics in a mouse skull defect model.
  • To investigate the influence of bioceramic size on bone regeneration outcomes.

Main Methods:

  • Bioceramics synthesized from human teeth analyzed using XRD, FTIR, and FE-SEM.
  • Ca/P molar ratio determined by ICP-MS (result: 1.67).
  • Cytotoxicity assessed via WST-1 assay with human alveolar bone marrow stem cells (hABMSCs) after simulated body fluid (SBF) soaking.

Main Results:

  • XRD and FTIR confirmed the characteristic peaks of HAp.
  • Bioceramics demonstrated no cytotoxicity and supported hABMSC adhesion, indicating biocompatibility.
  • Significant bone regeneration and enhanced vascularization observed in mice with bioceramic treatment, size-dependent.

Conclusions:

  • Human teeth-derived bioceramics are biocompatible and promote bone regeneration.
  • These bioceramics show promise as effective biomaterials for bone tissue engineering.
  • Bioceramic size is a critical factor influencing bone regeneration efficacy.