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Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
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Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

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Extracellular Vesicles in Diagnosing Chronic Coronary Syndromes the Bumpy Road to Clinical Implementation

Mirthe Dekker1,2, Farahnaz Waissi1,2, Nathalie Timmerman1

  • 1Department of Vascular Surgery, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

International Journal of Molecular Sciences
|December 3, 2020
PubMed

Insights

Extracellular vesicles (EVs) show promise as a blood-based biomarker for chronic coronary syndromes (CCS), a complex condition lacking reliable diagnostic tools. Further research into EV biomarkers could revolutionize CCS diagnosis and management.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Extracellular Vesicles

Background:

  • Coronary artery disease (CAD), including acute (ACS) and chronic (CCS) forms, is a leading global cause of mortality.
  • Current diagnostic methods for CCS, such as computed tomography and perfusion imaging, face challenges including cost, radiation exposure, and overuse in low-risk populations.
  • A significant unmet need exists for a reliable, blood-based biomarker for CCS diagnosis.

Purpose of the Study:

  • To review the potential of extracellular vesicles (EVs) as biomarkers for chronic coronary syndromes (CCS).
  • To discuss the clinical and technological considerations for the successful implementation of EV biomarkers in CCS diagnosis.

Main Methods:

  • Literature review focusing on extracellular vesicles (EVs) and their application in diagnosing chronic coronary syndromes (CCS).
  • Analysis of existing research on EV content (proteins, lipids, nucleic acids) as indicators of cardiovascular conditions.
  • Evaluation of clinical and technological challenges for EV biomarker integration into practice.

Main Results:

  • Extracellular vesicles (EVs), functioning as "liquid biopsies," contain bioactive molecules reflecting cellular states.
  • While extensively studied for cardiovascular applications, EVs are not yet standard clinical practice for CCS diagnosis.
  • EVs present a promising avenue for developing non-invasive, blood-based diagnostic tools for CCS.

Conclusions:

  • Extracellular vesicles (EVs) hold significant potential as a novel class of blood-based biomarkers for chronic coronary syndromes (CCS).
  • Addressing clinical and technological hurdles is crucial for translating EV research into routine diagnostic use for CCS.
  • Further development of EV biomarker assays could significantly improve the diagnosis and management of CCS.

Keywords:
angina pectorisbiomarkerchronic coronary syndrome (CCS)coronary artery disease (CAD)extracellular vesicles (EVs)liquid biopsy cardiovascular diseaseprotein

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