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Updated: Nov 27, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
[Periodontal complications with intrabony anesthesia]
Michael Laux1, Patrick R Schmidlin2
1Privatpraxis, Andelfingen, Schweiz.
Intraosseous anesthesia (IOA) offers rapid pain relief but carries risks like periodontal tissue necrosis and needle fracture, contrary to industry claims. Further clinical studies are needed to assess long-term IOA complications.
Area of Science:
- Dentistry
- Anesthesiology
- Periodontology
Background:
- Intraosseous anesthesia (IOA) involves injecting anesthetic directly into cancellous bone via cortical bone.
- IOA is recognized for its rapid onset, minimal soft tissue effects, and low anesthetic dosage.
- Industry claims suggest IOA is free from periodontal necrosis and needle fracture risks.
Purpose of the Study:
- To evaluate the clinical application and periodontal risks associated with intraosseous anesthesia.
- To investigate potential long-term complications, such as necrotic bone changes, following IOA.
- To present and discuss radiographic examples of complications based on existing literature.
Main Methods:
- Clinical evaluation of intraosseous anesthesia application.
- Radiographic analysis of potential periodontal and bone complications.
- Literature review of scarce existing studies on IOA risks.
Main Results:
- Clinical reports contradict industry statements, indicating risks of periodontal tissue necrosis and needle fracture with IOA.
- These complications are underreported in current literature, with IOA often presented as low-risk.
- Radiographic evidence and case examples highlight potential for adverse outcomes.
Conclusions:
- Intraosseous anesthesia, despite its advantages, presents risks that warrant greater clinical attention and research.
- The assumption of IOA's safety regarding periodontal structures and needle integrity is challenged by practical observations.
- Systematic clinical studies are essential to comprehensively document and understand the long-term effects and potential damage from intraosseous anesthesia.
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