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Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

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What does liver elastography measure? Technical aspects and methodology.

Christoph F Dietrich¹, Long Shi², Qi Wei³

¹Department Allgemeine Innere Medizin (DAIM), Kliniken Beau Site, Salem und Permanence, Hirslanden, Bern, Switzerland - c.f.dietrich@googlemail.com.

Minerva Gastroenterology

|December 3, 2020

Summary

This summary is machine-generated.

Shear wave elastography (SWE) offers a modern approach to assessing liver stiffness in diffuse liver disease, building upon the principles of palpation. This guide details SWE technologies, physics, and practical interpretation for clinical users.

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Area of Science:

Medical Imaging
Hepatology
Biophysics

Background:

Elastography evolved from palpation, offering quantitative tissue stiffness assessment.
Various elastography technologies exist, each with unique physical principles.
Diffuse liver diseases necessitate accurate assessment of liver stiffness.

Purpose of the Study:

To provide a comprehensive guide to shear wave elastography (SWE) for liver stiffness assessment.
To elucidate the technical aspects, methodologies, and terminology of SWE.
To assist both novice and experienced clinicians in understanding and applying SWE.

Main Methods:

Review of elastography history and technologies.
Focus on shear wave elastography (SWE) physics and application.
Inclusion of practical performance guidelines and interpretation factors for SWE.

Main Results:

Detailed explanation of SWE principles and available technologies.
Guidance on performing SWE and interpreting results in diffuse liver disease.
Clarification of technical aspects and terminology for clinical users.

Conclusions:

SWE is a valuable tool for assessing liver stiffness in diffuse liver disease.
Understanding SWE technology and proper interpretation is crucial for accurate diagnosis.
This guide enhances clinical application of SWE for improved patient management.