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Polysaccharide-Based Biomaterials in Tissue Engineering: A Review.

Min Jin1, Junli Shi2, Wenzhen Zhu3

  • 1Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR.

Tissue Engineering. Part B, Reviews
|December 3, 2020
PubMed
Summary

Polysaccharides are versatile biomaterials for tissue engineering (TE) due to their bioactivity and modifiability. This review details their properties and applications in regenerating various human tissues.

Keywords:
biological propertycrosslinking mechanismmodificationpolysaccharidesscaffoldstissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polysaccharides are abundant natural macromolecules with significant bioactivities.
  • Their properties resemble the extracellular matrix, making them suitable for biomedical applications.
  • Their non-toxic degradation and chemical modifiability enhance their potential in tissue engineering.

Purpose of the Study:

  • To review the essential chemical, crosslinking, and biological properties of polysaccharides.
  • To explore the structure-property relationships of polysaccharide-based biomaterials.
  • To summarize recent advancements and future prospects of polysaccharides in tissue engineering.

Main Methods:

  • Literature review of polysaccharide properties and applications in tissue engineering.
  • Analysis of chemical modification and crosslinking strategies.
  • Synthesis of information on diverse tissue regeneration applications.

Main Results:

  • Polysaccharides exhibit tunable mechanical properties and tissue responses through functional group modification.
  • Applications span bone, cartilage, cardiac, neural, and skin regeneration.
  • Understanding structure-property correlations is key to optimizing biomaterial design.

Conclusions:

  • Polysaccharide-based biomaterials offer significant potential for various tissue engineering applications.
  • Further research is needed to translate these materials into practical clinical treatments.
  • Continued investigation into their properties and fabrication holds promise for future biomedical innovations.