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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Updated: Nov 27, 2025

Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation
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XIST: A Meaningful Long Noncoding RNA in NSCLC Process.

Yujie Shen1, Yexiang Lin1, Kai Liu1

  • 1College of Medical Science, China Three Gorges University, Yichang 443002, China.

Current Pharmaceutical Design
|December 3, 2020
PubMed
Summary

Long non-coding RNA XIST is upregulated in non-small cell lung cancer (NSCLC), promoting tumor growth and affecting chemosensitivity. XIST shows potential as a therapeutic target and biomarker for NSCLC.

Keywords:
NSCLCRNAXISTbiomolecular markernoncodingtherapeutic target

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNA XIST is implicated in non-small cell lung cancer (NSCLC) development and chemosensitivity.
  • XIST is considered a potential therapeutic target for NSCLC patients.

Purpose of the Study:

  • To elucidate the biological functions and molecular mechanisms of XIST in NSCLC.

Main Methods:

  • Systematic literature review of studies on XIST and NSCLC using PubMed.

Main Results:

  • XIST is an oncogene abnormally upregulated in NSCLC tissues.
  • XIST critically influences NSCLC cell proliferation, invasion, migration, apoptosis, and chemosensitivity.
  • XIST primarily acts as a competing endogenous RNA (ceRNA) but also functions at the transcriptional level.

Conclusions:

  • Long non-coding RNA XIST demonstrates potential as a novel biomarker for NSCLC.
  • XIST represents a promising therapeutic target for NSCLC treatment.