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Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance

Dinesh S Moirangthem1, Laishram Surbala2

  • 1Food Safety Administration, Office of the Chief Medical Officer, Thoubal Wangma Taba, Thoubal District -795138, Manipur, India.

Current Drug Targets
|December 3, 2020
PubMed

Insights

Remdesivir, an antiviral drug, is being studied for its effectiveness against coronavirus disease 2019 (COVID-19). Clinical trials and compassionate use are exploring its role in treating hospitalized patients with COVID-19.

Area of Science:

  • * Virology and Infectious Diseases
  • * Pharmacology and Therapeutics

Background:

  • * The emergence of coronavirus disease 2019 (COVID-19) as a global pandemic necessitates urgent therapeutic strategies.
  • * Remdesivir, a nucleotide analog, is under investigation for its antiviral properties against SARS-CoV-2, the virus causing COVID-19.

Purpose of the Study:

  • * To review the development and mechanism of action of remdesivir.
  • * To summarize its use in COVID-19 patients under compassionate use and clinical trials.
  • * To assess the efficacy of remdesivir in treating COVID-19.

Main Methods:

  • * Literature review of remdesivir's journey, mechanism, and clinical applications.
  • * Analysis of data from compassionate use cases and ongoing clinical trials for COVID-19 treatment.

Main Results:

  • * Remdesivir functions by inhibiting the RNA-dependent RNA polymerase of SARS-CoV-2.
  • * Initial emergency use authorization was for severe COVID-19, now expanded to all hospitalized patients.

Conclusions:

  • * Remdesivir is an evolving therapeutic option for COVID-19.
  • * Its application has broadened from severe cases to all hospitalized patients under emergency use authorization.
Abstract

Keywords:
COVID-19GS-5734SARS-CoV-2coronavirus.pandemicremdesivir

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