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Splenic infarction and infectious diseases in Korea
Jae Hyoung Im1, Moon-Hyun Chung2, Hye-Jin Lee3
1Division of Infectious Diseases, Department of Internal Medicine, Inha University School of Medicine, Incheon, 22212, Republic of Korea.
BMC Infectious Diseases
|December 3, 2020
Summary
Splenic infarction (SI) is linked to various infections, particularly those caused by intracellular organisms. This study highlights the need for further research into the causes and mechanisms of SI in infectious disease contexts.
Area of Science:
- Infectious Diseases
- Hematology
- Radiology
Background:
- The spleen's immune function and unique infarction patterns suggest a link to infections.
- The relationship between splenic infarction (SI) and infectious diseases remains poorly understood.
- This study investigates the association between SI and various infectious conditions.
Purpose of the Study:
- To investigate the relationship between splenic infarction (SI) and infectious diseases.
- To identify common pathogens and clinical features associated with SI in infected patients.
Main Methods:
- Retrospective review of hospital records for patients diagnosed with SI.
- Data collection included clinical presentation, causative pathogens, risk factors, and radiological findings.
- Analysis focused on identifying associations between SI and infectious conditions.
Main Results:
- Of 353 SI patients, 101 had infectious conditions; intracellular organisms were most common (malaria, babesiosis, scrub typhus, EBV, CMV).
- Infective endocarditis (IE) occurred in 10 patients; bacteremia without IE in 26.
- Splenomegaly was more frequent in systemic infections; other organ infarction was rare.
Conclusions:
- Various infections are associated with SI, with intracellular pathogens being the most frequent cause.
- Further research is required to explore additional etiologies and the pathophysiological mechanisms of SI.
- Understanding SI's infectious links can improve diagnosis and patient management.
