Related Experiment Video
Updated: Nov 27, 2025

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
NGS-based typings for 7 HLA loci in three populations from Rio de Janeiro, RJ, Brazil
Romulo Vianna1, Leonardo Hanhoerderster1, Juliana Cardoso1
1Laboratório de Histocompatibilidade e Criopreservação, Universidade do Estado do Rio de Janeiro, Avenida Marechal Rondon 381, 20950-003 Rio de Janeiro, Brazil.
Abstract:
We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 759 Brazilian individuals from three populations in the Rio de Janeiro city based on their self-declared skin color (Caucasian, N = 521, AFND-ID: 3730; Parda, N = 170, AFND-ID: 3728; Black, N = 68, AFND-ID: 3727) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. Only HLA-DRB1 locus deviated from Hardy-Weinberg equilibrium (in Caucasian and Black populations). The three populations shared the most frequent allele on HLA-A, -C, -DRB1, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database.
More Related Videos
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Incomplete Dominance
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs

