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Repeatability of corneal biomechanics waveform signal parameters derived from Ocular Response Analyzer in children
Kin Wan1, Sin Wan Cheung1, James Stuart Wolffsohn2
1Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Insights
Six key waveform signal parameters measured by the Ocular Response Analyzer (ORA) demonstrate good repeatability in children, providing foundational data for future clinical applications.
Area of Science:
- Ophthalmology
- Optometry
- Biomedical Engineering
Background:
- The Ocular Response Analyzer (ORA) measures corneal biomechanical properties.
- Waveform signal parameters from ORA have potential clinical applications, but their repeatability in children is not well-established.
- Understanding repeatability is crucial for reliable clinical use in pediatric populations.
Purpose of the Study:
- To assess the repeatability of ORA waveform signal parameters in children.
- To determine the reliability of specific ORA parameters for pediatric use.
Main Methods:
- Two sets of ORA measurements were taken from children (6-11 years old) wearing single-vision spectacles or orthokeratology lenses, with a 10-minute interval.
- Intraclass correlation coefficients (ICCs) and Bland-Altman (BA) plots were used to analyze the agreement of 37 waveform signal parameters.
- Data from 30 participants were pooled due to no significant group differences.
Main Results:
- Six parameters (h2, h21, p1area, p1area1, p2area, p2area1) showed moderate to excellent repeatability with ICCs ranging from 0.82 to 0.85.
- Bland-Altman analysis confirmed considerable agreement for these six parameters, indicating good reliability.
- These parameters relate to the areas under the waveform signal peaks.
Conclusions:
- Specific ORA waveform signal parameters exhibit moderate to excellent repeatability in children.
- These findings provide essential data for future research into the clinical utility of these parameters in pediatric ophthalmology and optometry.
- The study supports the potential use of these parameters for monitoring eye conditions in children.
Purpose:
To investigate the repeatability of waveform signal parameters, measured with the Ocular Response Analyzer (ORA), in children.
Methods:
Two sets of ORA measurements, with a 10-min break between them, were performed on children, aged six to <11 years old, either wearing single-vision spectacles (SVS) or orthokeratology (ortho-k) lenses. Intraclass correlation coefficients (ICCs) were used to assess agreements between two sets of measurements (37 waveform signal parameters). Bland-Altman (BA) plots were used to further analyse waveform signal parameters which had ICC 95 % confidence interval (95 % CI) between 0.50 to >0.90 (regarded as moderate to excellent agreement).
Results:
A total of 30 participants [15 SVS, 15 ortho-k (3.6 ± 2.4 months)] completed the study. Since no significant between-group differences were detected in demographic data (p > 0.28) and all waveform signal parameters (p > 0.05), data from the two groups of participants were pooled for the analysis of repeatability. Six parameters, h2, h21, p1area, p1area1, p2area, and p2area1, achieved ICCs (95 % CI) of 0.82-0.85 (0.61-0.93). The mean (SD) of these six parameters were 372 (91), 248 (61), 4077 (854), 1762 (399), 2359 (670), and 1020 (300), respectively. Bland-Altman plots and 95 % limits of agreement (95 % LoA) showed considerable agreement for all six parameters, the mean difference (95 % LoA) were -3 (-101 to 94), -2 (-67.56-62.70), 111 (-723 to 946), 102 (-334 to 539), 25 (-718 to 768), and -3 (-350 to 343), respectively.
Conclusions:
Six waveform signal parameters (h2, h21, p1area, p1area1, p2area, and p2area1), which represent or are related to the areas under the waveform at the peaks in the signal, had moderate to excellent agreement in children. Results of the current study provides fundamental information for further studies on the potential clinical application of these waveform signal parameters in children.
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