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Related Experiment Video

Updated: Nov 27, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

COVID-19 and Acute Sarcopenia.

Carly Welch^1,2,3, Carolyn Greig^2,4,5, Tahir Masud^2,6,7

¹1Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

Aging and Disease

|December 3, 2020

Summary

COVID-19 survivors, especially older adults and critically ill patients, are at risk of acute sarcopenia, a sudden muscle insufficiency. Early recognition and multidisciplinary care are crucial for managing this under-recognized condition.

Keywords:

COVID-19 acute sarcopenia

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Published on: March 21, 2021

Area of Science:

Gerontology
Infectious Diseases
Muscle Physiology

Background:

COVID-19 disproportionately affects older adults, increasing mortality risk.
Survivors of COVID-19, particularly the elderly and critically ill, are susceptible to acute sarcopenia.
Acute sarcopenia, characterized by rapid muscle function/quantity decline post-stressor, is an under-recognized complication.

Purpose of the Study:

To review the definition and mechanisms of acute sarcopenia in COVID-19 patients.
To propose recommendations for future research and clinical practice regarding acute sarcopenia.

Main Methods:

Literature review and expert commentary on acute sarcopenia in the context of COVID-19.
Analysis of existing definitions and proposed pathophysiological pathways.
Synthesis of current clinical observations and treatment considerations.

Main Results:

Acute sarcopenia is defined by muscle function/quantity loss within six months post-stressor event.
Older adults and severely ill COVID-19 patients face the highest risk.
Mechanisms linking COVID-19 to acute sarcopenia require further elucidation.

Conclusions:

Further research is essential to understand the long-term consequences of acute sarcopenia in COVID-19 survivors.
Clinicians must increase awareness and integrate muscle health assessments into routine practice.
Multidisciplinary management, including nutritional support, is recommended for patients at risk.