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Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports
Masaki Okajima1, Yoshinori Takahashi2, Takaaki Kaji3
1Intensive Care Unit, Kanazawa University Hospital, Kanazawa 920-8641, Ishikawa, Japan. mmokaji@gmail.com.
Background:
Nafamostat mesylate (NM) may prove to be one of the key drugs effective against coronavirus disease 2019 (COVID-19) because of its anti-viral properties and the potential to manage coagulopathy. However, NM tends to increase serum potassium levels.
Case Summary:
We observed hyperkalemia immediately after NM administration (200 mg/d) in four consecutive patients who were admitted to the Kanazawa University Hospital with severe COVID-19 pneumonia. Urinary potassium excretion decreased after NM administration in three patients who underwent urinalysis.
Conclusion:
NM is likely to produce hyperkalemia in patients with COVID-19. Therefore, it is necessary to monitor serum potassium values closely after NM initiation in COVID-19 patients who need respiratory support.
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