Laboratory Acquired Zika Virus Infection Through Mouse Bite: A Case Report
Mariane Talon de Menezes1, Raíssa Rilo Christoff2, Luiza M Higa1
1Institute of Biology, Department of Genetic, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Abstract:
Zika virus is an arthropod-borne flavivirus mainly transmitted by the bite of infected mosquitoes. However, alternative transmission routes can occur. In this study, we show the accidental transmission of virus from an infected mouse to a human during the experimental manipulation. This study describes the patient clinical manifestations and virus genome identification.
Insights
Accidental human transmission of Zika virus occurred from an infected mouse during laboratory work. This study details the patient's symptoms and identifies the specific Zika virus genome involved.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Zika virus is a flavivirus primarily transmitted by mosquito vectors.
- Understanding non-vectorial transmission is crucial for public health.
- Alternative transmission routes beyond arthropod bites are possible.
Observation:
- An accidental human transmission of Zika virus was documented.
- This event occurred during experimental manipulation involving an infected mouse.
- The transmission route was not through mosquito bite.
Findings:
- The study details the clinical manifestations observed in the infected patient.
- The specific genome of the transmitted Zika virus was identified.
- This provides evidence for direct animal-to-human transmission in a laboratory setting.
Implications:
- Highlights potential risks in laboratory settings with infected animal models.
- Underscores the need for stringent biosafety protocols when handling Zika virus.
- Informs future research on non-vectorial transmission routes of flaviviruses.
