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Updated: Nov 27, 2025

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
Published on: December 27, 2016
Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological
Raheel Khan1, Don Kulasiri1, Sandhya Samarasinghe2
1Centre for Advanced Computational Solutions (C-fACS), Lincoln University; Department of Molecular Biosciences, Lincoln University, Christchurch, New Zealand.
Abstract:
Protein phosphorylation and dephosphorylation are two essential and vital cellular mechanisms that regulate many receptors and enzymes through kinases and phosphatases. Ca2+- dependent kinases and phosphatases are responsible for controlling neuronal processing; balance is achieved through opposition. During molecular mechanisms of learning and memory, kinases generally modulate positively while phosphatases modulate negatively. This review outlines some of the critical physiological and structural aspects of kinases and phosphatases involved in maintaining postsynaptic structural plasticity. It also explores the link between neuronal disorders and the deregulation of phosphatases and kinases.
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