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CTRP3 and serum triglycerides in children aged 7-10 years
Arsham Alamian1, Jo-Ann Marrs2, W Andrew Clark3
1School of Nursing and Health Studies, University of Miami, Coral Gables, Florida, United States of America.
Plos One
|December 3, 2020
Summary
The middle molecular weight (MMW) form of CTRP3, not total levels, is linked to lower triglycerides and VLDL in children. This finding highlights the importance of CTRP3’s oligomeric state in metabolic health.
Area of Science:
- Metabolic Health
- Pediatric Endocrinology
- Biochemistry
Background:
- Rising obesity-related disorders in children, including hyperlipidemia.
- C1q TNF Related Protein 3 (CTRP3) involvement in triglyceride regulation, primarily studied in animal models.
- Controversy surrounding the link between circulating CTRP3 levels and human obesity-related disorders.
- CTRP3 exists in various oligomeric complexes (trimeric, middle molecular weight (MMW), and high molecular weight (HMW)).
- Previous research suggests CTRP3 oligomeric state, not total concentration, is key to its association with serum lipids.
Purpose of the Study:
- To investigate the relationship between different CTRP3 oligomeric complexes and circulating lipid levels in young children.
- To determine if CTRP3 oligomeric state is a significant factor in pediatric metabolic health.
Main Methods:
- Cross-sectional study of 62 Hispanic children (aged 7-10 years).
- Collected morphometric data and serum samples for analysis of various biomarkers including CTRP3 oligomers, lipids, insulin, and inflammatory markers.
- Utilized correlation analyses to examine relationships between CTRP3 forms and other biomarkers.
Main Results:
- Total CTRP3 concentrations showed positive correlations with total cholesterol and HDL cholesterol.
- High molecular weight (HMW) CTRP3 was not significantly associated with any measured variables.
- Middle molecular weight (MMW) CTRP3 demonstrated significant negative correlations with triglycerides, VLDL, insulin, and BMI.
- Strong negative correlations were observed between MMW CTRP3 and triglycerides (r² = -0.826) and VLDL (r² = -0.827).
Conclusions:
- The circulating oligomeric state of CTRP3 is crucial for understanding its association with metabolic diseases, rather than total CTRP3 levels alone.
- MMW CTRP3 plays a significant role in regulating triglycerides and VLDL in children.
- Further research is warranted to elucidate the precise mechanisms of MMW CTRP3 in metabolic regulation.
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