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The case for an HIV cure and how to get there
Mark Dybul1, Timothy Attoye2, Solange Baptiste3
1Center for Global Health Practice and Impact, Georgetown University, Washington, DC, USA.
The Lancet. HIV
|December 3, 2020
Summary
Accelerating the development of an HIV cure is crucial to complement prevention efforts and overcome treatment limitations. Establishing the HIV Cure Africa Acceleration Partnership (HCAAP) will unite stakeholders to advance HIV cure research and product adoption.
Area of Science:
- Global Health
- Infectious Disease Research
- HIV/AIDS Research
Background:
- The global burden of new HIV infections necessitates urgent development of a cure.
- Existing prevention and treatment modalities face limitations and financial challenges.
- A curative intervention offers potential to prevent infections, reduce stigma, and provide sustainable pandemic control.
Purpose of the Study:
- To propose actionable steps for planning and accelerating HIV cure development.
- To introduce the HIV Cure Africa Acceleration Partnership (HCAAP) as a catalyst for research.
- To emphasize early and inclusive stakeholder engagement in cure product development.
Main Methods:
- Defining a target product profile for an effective HIV cure.
- Establishing a multidisciplinary public-private partnership (HCAAP).
- Engaging diverse stakeholders, including people living with HIV, from the outset.
Main Results:
- The proposed partnership (HCAAP) aims to catalyze and promote HIV cure research.
- Early stakeholder engagement is key to designing socially acceptable and adoptable cure products.
- A strategic approach is needed to accelerate the delivery of an HIV cure.
Conclusions:
- An accelerated, collaborative approach is essential to achieve an HIV cure.
- The HCAAP model promotes multidisciplinary engagement for rapid progress.
- Successful HIV cure development requires planning, partnership, and inclusive design.
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