Diabetes pharmacotherapy and circulating stem/progenitor cells. State of the art and evidence gaps

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Mattia Albiero1, Benedetta Maria Bonora1, Gian Paolo Fadini1

  • 1Department of Medicine, University of Padova, 35128 Padova, Italy; Veneto Institute of Molecular Medicine, 35128 Padova, Italy.

Current Opinion in Pharmacology
|December 3, 2020
PubMed

Insights

Diabetes pharmacotherapy impacts hematopoietic stem/progenitor cells (HSPCs) and endothelial progenitor cells (EPCs), crucial for tissue repair. Understanding these effects is key to managing diabetic complications.

Area of Science:

  • Endocrinology and Regenerative Medicine
  • Stem Cell Biology and Diabetes Research

Background:

  • Diabetes mellitus is characterized by end-organ damage and increased mortality, stemming from impaired damage control and inadequate repair processes.
  • Hematopoietic stem/progenitor cells (HSPCs) and endothelial progenitor cells (EPCs) are vital for tissue homeostasis and serve as biomarkers for diabetic complication risk.

Purpose of the Study:

  • To review the current understanding of how diabetes pharmacotherapy affects circulating HSPCs and EPCs.
  • To identify knowledge gaps regarding the influence of diabetes medications on these critical cell populations.

Main Methods:

  • Literature review of studies investigating the effects of various diabetes medications on HSPC and EPC levels.
  • Analysis of existing research on the role of HSPCs and EPCs in diabetic complications.

Main Results:

  • Diabetes pharmacotherapy exhibits varied effects on HSPC and EPC populations, with some agents potentially enhancing or diminishing their levels.
  • The precise impact of different drug classes on these progenitor cells requires further elucidation.

Conclusions:

  • Targeting HSPCs and EPCs represents a potential therapeutic strategy for mitigating diabetic complications.
  • Further research is essential to fully comprehend the interplay between diabetes medications, progenitor cells, and complication development.

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