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Pulmonary hypertension and mitral regurgitation in an infant with an anatomically normal mitral valve

Ryan Hoang1, William Cohen1, Shireen Mukadam2

  • 1Section of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA.

Cardiology in the Young
|December 4, 2020
PubMed

A full-term, female presented on her date of birth with severe pulmonary hypertension (PH) and mitral regurgitation (MR), requiring veno-arterial extracorporeal membrane oxygenation. After the treatment, her PH and MR were resolved with no anatomic abnormality present. We propose a positive feedback loop of PH causing right ventricular dilation and interventricular septal shifts, worsening MR, and elevated left atrial, and potentially pulmonary, pressures.

Keywords:
Mitral regurgitationPPHNfeedback looppulmonary hypertensionseptal geometry

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