Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Overview of the Vascular System

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...

Varicose Veins I: Introduction

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...

Esophageal Varices-II: Clinical Features and Management

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Standardizing Global Pediatric Stroke Pathways: Insights From a Global Survey Conducted by the Society of Neurointerventional Surgery Pediatric Special Interest Group.

Stroke (Hoboken, N.J.)·2026

Same author

Real-World Safety Profile of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: a Multinational Multicenter Study.

Clinical neuroradiology·2026

Same author

Cerebrovascular vulnerability and fibrosis in human brain aneurysms.

Nature neuroscience·2026

Same author

Extramedullary Intradural Spinal Tumor in an Infant With Neurocutaneous Melanosis.

Pediatric blood & cancer·2026

Same author

Temporal relationship between hematoma resolution and functional recovery after middle meningeal artery embolization for chronic subdural hematoma.

Journal of neurosurgery·2026

Same author

Diagnostic cerebral angiography: A report of the SNIS Standards and Guidelines Committee, endorsed by ANZSNR and ESMINT.

Journal of neurointerventional surgery·2026

Same journal

Preface.

Handbook of clinical neurology·2026

Same journal

Foreword.

Handbook of clinical neurology·2026

Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026

Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026

Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026

Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 27, 2025

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

Vascular anomalies: Classification and management.

Kazim H Narsinh¹, Ayushi Gautam¹, Amanda Baker¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.

Handbook of Clinical Neurology

|December 4, 2020

Summary

This summary is machine-generated.

Vascular anomalies, including tumors and malformations, are often caused by gene mutations. Understanding these genetic pathways is key to developing new treatments and improving diagnosis.

Keywords:

Sclerotherapy Vascular anomalies Vascular malformations Vascular tumors

More Related Videos

A Patient-Derived Xenograft Model for Venous Malformation

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Related Experiment Videos

Last Updated: Nov 27, 2025

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

A Patient-Derived Xenograft Model for Venous Malformation

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Area of Science:

Vascular biology and genetics
Medical diagnostics and therapeutics

Background:

Vascular anomalies encompass vascular tumors and malformations.
Sporadic mosaic gene mutations are the primary cause of most vascular anomalies.
Recent genetic research has significantly improved understanding of their pathogenesis.

Purpose of the Study:

To integrate molecular insights with the International Society for Study of Vascular Anomalies classification.
To highlight genetic, radiologic, and interventional approaches for diagnosis and management.
To foster multidisciplinary collaboration for complex vascular anomalies.

Main Methods:

Review of recent genetic studies on vascular anomaly pathogenesis.
Integration of molecular findings into the current ISSVA classification.
Emphasis on diagnostic and management strategies including genetics, radiology, and interventions.

Main Results:

Improved understanding of molecular pathways driving vascular anomalies.
Updated classification reflecting new pathogenetic insights.
Identification of targeted therapeutic strategies based on molecular mechanisms.

Conclusions:

Molecular understanding is crucial for classifying and treating vascular anomalies.
Multidisciplinary collaboration enhances the management of these conditions.
Genetic, radiologic, and interventional approaches are vital for comprehensive care.