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Interventional neuro-oncology.

Monica S Pearl1, Nalin Gupta2, Steven W Hetts3

  • 1Division of Interventional Neuroradiology, Johns Hopkins Hospital, Baltimore, MD, United States; Department of Radiology, Children's National Medical Center, Washington, DC, United States.

Handbook of Clinical Neurology
|December 4, 2020
PubMed
Summary
This summary is machine-generated.

Interventional neuro-oncology uses image-guided therapies like intra-arterial chemotherapy and blood-brain barrier disruption for brain and head/neck tumors. These minimally invasive techniques aim to improve treatment delivery and outcomes.

Keywords:
Blood–brain barrier disruptionDrug deliveryInterventionalIntra-arterial chemotherapy

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Area of Science:

  • Interventional Radiology
  • Neuro-oncology
  • Image-Guided Therapy

Background:

  • Interventional neuro-oncology offers advanced treatment options for brain, eye, and head and neck tumors.
  • Minimally invasive, image-guided techniques are crucial for delivering therapies directly to tumors.
  • Traditional treatments may have limitations in drug delivery and efficacy for certain head and neck cancers.

Purpose of the Study:

  • To discuss the spectrum of interventional neuro-oncology techniques.
  • To highlight image-guided therapies for treating tumors in the brain, eye, and head and neck regions.
  • To review methods for enhancing therapeutic agent delivery.

Main Methods:

  • Intra-arterial chemotherapy
  • Regional drug delivery
  • Chemoembolization
  • Tumor ablation
  • Blood-brain barrier disruption (physical and chemical)
  • Percutaneous catheter placement

Main Results:

  • Image-guided therapies provide targeted treatment options.
  • Techniques like blood-brain barrier disruption can improve drug delivery efficacy.
  • Percutaneous approaches enable minimally invasive interventions.
  • Chemoembolization and tumor ablation offer localized tumor control.

Conclusions:

  • Interventional neuro-oncology represents a significant advancement in treating head and neck tumors.
  • Image-guided, minimally invasive techniques are essential for optimizing therapeutic delivery.
  • These approaches hold promise for improved patient outcomes in neuro-oncology.