Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The neurobiology of survivorship: Cognitive consequences of modern oncology.

Neuro-oncology advances·2026
Same author

Epilepsy characteristics and outcomes in patients with pleomorphic xanthoastrocytomas.

Journal of neuro-oncology·2026
Same author

Phase 1 evaluation of patients with newly diagnosed glioblastoma treated with radiation, nivolumab, and IDO1 enzyme inhibitor BMS-986205.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

From barrier to bridge: a scoping review on the methods, clinical efficacy, and safety of blood-brain barrier disruption in treating high-grade glioma.

Journal of neuro-oncology·2026
Same author

Survival and function in elderly patients with GBM: the role of surgical resection with contemporary multimodal therapy.

Journal of neuro-oncology·2026
Same author

Neurogenetic tumor syndromes: The current landscape of workup and treatment.

Neuro-oncology practice·2026

Related Experiment Video

Updated: Nov 27, 2025

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

18.4K

Nonmalignant Brain Tumors.

Rimas V Lukas, Maciej M Mrugala

    Continuum (Minneapolis, Minn.)
    |December 4, 2020
    PubMed
    Summary

    This review covers the diagnosis and management of common brain tumors like meningiomas and pituitary adenomas. Advances in molecular biology offer potential targeted therapies for these and other tumors such as craniopharyngiomas and glioneuronal tumors.

    Area of Science:

    • Neuro-oncology
    • Neurosurgery
    • Molecular Pathology

    Background:

    • Meningiomas and pituitary adenomas are common brain tumors, often found incidentally.
    • These nonmalignant tumors can cause significant morbidity and, rarely, transform into malignant variants.
    • Understanding molecular subtypes is crucial for effective treatment strategies.

    Purpose of the Study:

    • To describe the diagnosis and management of meningioma, pituitary adenoma, craniopharyngioma, and glioneuronal tumors.
    • To highlight recent advancements in understanding the molecular biology of these neoplasms.
    • To discuss the potential of targeted therapies for nonmalignant brain tumors.

    Main Methods:

    • Review of current literature on the diagnosis and management of specific brain tumor types.

    More Related Videos

    Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
    10:58

    Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

    Published on: February 22, 2015

    13.2K
    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
    07:44

    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

    Published on: May 2, 2025

    613

    Related Experiment Videos

    Last Updated: Nov 27, 2025

    Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
    08:14

    Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

    Published on: September 25, 2012

    18.4K
    Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
    10:58

    Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

    Published on: February 22, 2015

    13.2K
    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
    07:44

    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

    Published on: May 2, 2025

    613
  • Analysis of recent findings in molecular biology and genetic alterations.
  • Evaluation of surgical and medical therapeutic modalities.

    • Main Results:

    • Surgical techniques enable more complete resections with reduced complications.
    • Molecular biology insights are leading to targeted therapies, especially for meningiomas.
    • Medical therapies for secretory pituitary adenomas are continuously improving.
    • Craniopharyngiomas and glioneuronal tumors exhibit molecular subtypes with potential for targeted treatment.
    • Over half of glioneuronal tumors show targetable molecular alterations.

    Conclusions:

    • Familiarity with presentation and management of meningiomas and pituitary adenomas is essential for neurologists.
    • Meningiomas, craniopharyngiomas, and glioneuronal tumors frequently have actionable genetic alterations.
    • Targeted therapies are emerging as a supplement to surgical treatment for these nonmalignant tumors.