Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

92
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
92
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

111
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
111
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

138
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
138

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The neurobiology of survivorship: Cognitive consequences of modern oncology.

Neuro-oncology advances·2026
Same author

A prognostic human brain network for diffuse midline glioma.

Nature·2026
Same author

Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice.

bioRxiv : the preprint server for biology·2026
Same author

KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS.

JCI insight·2026
Same author

Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy.

Cell death & disease·2026
Same author

Pediatric H3 G34-mutant diffuse hemispheric glioma: clinical, imaging and molecular prognostic factors, MGMT expression, and temozolomide response.

Acta neuropathologica·2026
Same journal

Key Considerations in Telestroke Program Management.

Continuum (Minneapolis, Minn.)·2026
Same journal

Neurology's Action Potential: Delivering on the Promise of Brain Health.

Continuum (Minneapolis, Minn.)·2026
Same journal

Erratum.

Continuum (Minneapolis, Minn.)·2026
Same journal

Management of Large Artery Atherosclerosis.

Continuum (Minneapolis, Minn.)·2026
Same journal

Thrombolysis, Thrombectomy, and Antithrombotic Therapy for Acute Ischemic Stroke.

Continuum (Minneapolis, Minn.)·2026
Same journal

Stroke in Children and Younger Adults.

Continuum (Minneapolis, Minn.)·2026
See all related articles

Related Experiment Video

Updated: Nov 27, 2025

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

613

Pediatric Brain Tumors.

Sonia Partap, Michelle Monje

    Continuum (Minneapolis, Minn.)
    |December 4, 2020
    PubMed
    Summary
    This summary is machine-generated.

    Pediatric brain tumors are complex and differ from adult cancers. Molecular classifications and clinical trial findings are improving diagnosis, treatment, and outcomes for children.

    More Related Videos

    Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors
    11:14

    Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors

    Published on: September 24, 2014

    16.0K
    Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
    03:13

    Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

    Published on: June 28, 2024

    1.0K

    Related Experiment Videos

    Last Updated: Nov 27, 2025

    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
    07:44

    Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

    Published on: May 2, 2025

    613
    Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors
    11:14

    Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors

    Published on: September 24, 2014

    16.0K
    Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
    03:13

    Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

    Published on: June 28, 2024

    1.0K

    Area of Science:

    • Pediatric oncology
    • Neuro-oncology
    • Molecular pathology

    Background:

    • Pediatric brain tumors are distinct from adult brain cancers due to the developing brain.
    • Treatment aims to balance neurocognitive outcomes with long-term survival.
    • The 2016 World Health Organization classification integrated molecular features for diagnosis and prognosis.

    Purpose of the Study:

    • To review primary brain tumors in pediatric patients.
    • To emphasize molecular classifications and current treatment strategies.
    • To discuss recent advancements and their impact on patient care.

    Main Methods:

    • Review of recent clinical trial findings.
    • Analysis of molecular stratification in pediatric brain tumors.
    • Integration of updated diagnostic and prognostic criteria.

    Main Results:

    • Molecular characteristics aid in defining diagnosis and prognosis.
    • Stratification allows for intensified therapy in high-risk cases and reduced morbidity.
    • Recent trials have yielded significant insights for gliomas, embryonal tumors, and ependymomas.
    • Identification of molecular factors correlating with survival and predisposing germline mutations.

    Conclusions:

    • New findings and molecular stratification will guide future pediatric brain tumor therapies.
    • Research aims to improve overall outcomes and identify tumorigenesis pathways.
    • Genetic counseling for affected children and families will be enhanced.