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Updated: Nov 27, 2025
Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG hOMING
Published on: March 14, 2019
Serum Glycomics on Postoperative Day 7 Are Associated With Graft Loss Within 3 Months After Liver Transplantation
Xavier Verhelst1,2,3, Anja Geerts1,2,3, Roos Colman4
1Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.
Background:
Prediction of outcome after liver transplantation (LT) is limited by the lack of robust predictors of graft failure. In this prospective study, we aimed to define a serum glycomic signature in the first week after LT that is associated with graft loss at 3 mo after LT.
Methods:
Patients were included between January 1, 2011, and February 28, 2017. Glycomic analysis was performed using DNA sequencer-associated fluorophore-associated capillary electrophoresis on a serum sample 1 wk after LT. Making use of Lasso regression, an optimal glycomic signature was identified associated with 3-mo graft survival.
Results:
In this cohort of 131 patients, graft loss at 3 mo occurred in 14 patients (11.9%). The optimal mode, called the GlycoTransplantTest, yielded an area under the curve of 0.95 for association with graft loss at 3 mo. Using an optimized cutoff for this biomarker, sensitivity was 86% and specificity 89%. Negative predictive value was 98%. Odds ratio for graft loss at 3 mo was 70.211 (P < 0.001; 95% confidence interval, 10.876-453.231).
Conclusions:
A serum glycomic signature is highly associated with graft loss at 3 mo. It could support decision making in early retransplantation.
