Could sST2 Predict Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction?
Ahmet Avcı1, Mustafa Umut Somuncu1, Murat Can2
1Department of Cardiology, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
International Journal of General Medicine
|December 4, 2020
Summary
Soluble suppression of tumorigenesis-2 (sST2) levels can help predict contrast-induced nephropathy (CIN) in patients with ST-elevation myocardial infarction (STEMI). Higher sST2 levels indicate a greater risk of developing CIN after percutaneous coronary interventions.
Area of Science:
- Cardiology
- Nephrology
- Biomarkers
Background:
- Contrast-induced nephropathy (CIN) is a serious complication of percutaneous coronary interventions (PCI) in myocardial infarction (MI).
- Soluble suppression of tumorigenesis-2 (sST2) is implicated in inflammatory processes, cardiac remodeling, and fibrosis.
Purpose of the Study:
- To investigate the potential of sST2 as a predictor of CIN development in ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI.
- To identify independent risk factors for CIN in this patient population.
Main Methods:
- A cross-sectional observational study involving 357 consecutive STEMI patients.
- Comparison of demographic, medical history, laboratory, and procedural characteristics between patients who developed CIN and those who did not.
- Multivariate logistic regression analysis to determine independent predictors of CIN.
Main Results:
- 81 patients (22.7%) developed CIN.
- Patients with CIN had significantly higher sST2 concentrations (40.6±21.0 ng/mL vs 31.5±13.0 ng/L, p<0.001).
- Independent predictors of CIN included diabetes mellitus, lower eGFR, lower systolic blood pressure, longer procedure time, and higher sST2 levels. High sST2 levels increased CIN risk by 3.06 times.
Conclusions:
- sST2 levels measured on admission are valuable for predicting CIN development in STEMI patients.
- sST2 serves as an independent predictor of CIN, offering prognostic value beyond traditional risk factors.
Keywords:
ST-elevation myocardial infarctioncontrast-induced nephropathyprimary percutaneous coronary interventionsoluble ST2More Related Videos
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