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Differential Network Analysis Reveals Molecular Determinants Associated with Blood Pressure and Heart Rate in Healthy
Alessia Vignoli1,2, Leonardo Tenori2,3, Claudio Luchinat1,2,3
1Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), 50019 Sesto Fiorentino, Italy.
Insights
Subclinical high blood pressure and heart rate in healthy adults are linked to metabolic pathway changes. These findings suggest underlying cardiometabolic dysregulations may predispose individuals to future cardiovascular disease.
Area of Science:
- Cardiovascular Health
- Metabolomics
- Systems Biology
Background:
- Subclinical elevations in blood pressure and heart rate during youth and adulthood are associated with increased future cardiovascular disease risk.
- Understanding the underlying mechanisms of these subclinical changes in healthy individuals is crucial for early intervention.
- Metabolic dysregulations may play a significant role in the development of subclinical hypertension and tachycardia.
Purpose of the Study:
- To investigate the metabolic differences between healthy adults with subclinical low and high blood pressure and heart rate.
- To identify specific metabolic pathways and molecular networks associated with subclinical cardiometabolic risk factors.
- To explore the potential of metabolomics for detecting latent cardiometabolic dysregulations.
Main Methods:
- A network-based metabolomic study was conducted on blood plasma samples from 841 healthy adult blood donors.
- Metabolites and lipids were measured using nuclear magnetic resonance (NMR) spectroscopy.
- Participants were stratified based on subclinical systolic and diastolic blood pressure and heart rate levels.
Main Results:
- Significant rewiring of metabolic pathways was observed when comparing individuals with subclinical high versus low blood pressure and heart rate.
- Specific metabolite and lipid profiles differed between the high and low blood pressure/heart rate groups, indicating distinct metabolic states.
- The findings suggest that individuals with subclinical high blood pressure and heart rate exhibit latent metabolic alterations.
Conclusions:
- Subclinical elevations in blood pressure and heart rate in healthy adults are associated with distinct metabolic pathway alterations.
- Metabolomic profiling can reveal latent cardiometabolic dysregulations in seemingly healthy individuals.
- These findings highlight the potential of metabolic network analysis for early identification of cardiovascular disease risk.
Abstract:
There is mounting evidence that subclinical nonpathological high blood pressure and heart rate during youth and adulthood steadily increase the risk of developing a cardiovascular disease at a later stage. For this reason, it is important to understand the mechanisms underlying the subclinical elevation of blood pressure and heart rate in healthy, relatively young individuals. In the present study, we present a network-based metabolomic study of blood plasma metabolites and lipids measured using nuclear magnetic resonance spectroscopy on 841 adult healthy blood donor volunteers, which were stratified for subclinical low and high blood pressure (systolic and diastolic) and heart rate. Our results indicate a rewiring of metabolic pathways active in high and low groups, indicating that the subjects with subclinical high blood pressure and heart rate could present latent cardiometabolic dysregulations.
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