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Serum periostin levels in adolescents
Yosuke Nakamura1, Yuko Yokoyama1, Kenichiro Nakajima1,2
1Division of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University.
Asian Pacific Journal of Allergy and Immunology
|December 4, 2020
Summary
Serum periostin levels are elevated in adolescents with allergic diseases, suggesting its potential as a biomarker. Bone metabolism appears to have limited impact on periostin levels in this age group.
Area of Science:
- Pediatric Allergy and Immunology
- Biomarker Discovery
- Adolescent Health
Background:
- Periostin is a known biomarker for Th2-induced airway inflammation in adults with allergic diseases.
- Its utility in pediatric allergic diseases and the influence of adolescent bone metabolism remain unclear.
- This study investigates periostin as a potential biomarker in adolescents.
Purpose of the Study:
- To evaluate the relationship between serum periostin levels and allergic diseases in adolescents.
- To investigate periostin levels in relation to allergic disease prevalence and sensitization.
- To explore the potential impact of adolescent bone metabolism on periostin levels.
Main Methods:
- Cross-sectional observational study of 100 adolescents (ages 9-15).
- Serum periostin levels measured via Enzyme-Linked Immuno Sorbent Assay (ELISA).
- Allergic diseases and sensitization assessed through surveys and Multiple Antigen Simultaneous Test (MAST).
Main Results:
- No significant differences in periostin levels were observed between pre-early and post-early adolescent groups or by gender.
- Age and Body Mass Index showed no significant association with periostin levels.
- Adolescents with allergic diseases exhibited significantly higher serum periostin levels compared to healthy controls (41.6 vs. 28.6 ng/ml, P < 0.05).
Conclusions:
- Serum periostin levels are elevated in adolescents with allergic diseases, indicating potential as a biomarker.
- Bone metabolism likely has a limited effect on serum periostin levels in the 9-15 year age range.
- Further research is needed to establish reference values for periostin in adolescents.
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