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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
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Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

129
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

137
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
137

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Evaluation of the determinants of FVIII/FIX levels, bleeding score, and health-related quality of life in the Canadian hemophilia carriers (CHiC) study.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Management of women with type 2B von Willebrand disease during pregnancy and postpartum: guidance from ISTH SSC subcommittees on von Willebrand factor and women's health issues in thrombosis and hemostasis.

Journal of thrombosis and haemostasis : JTH·2026
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Performing Large-Scale Genetic Analysis in the Bleeding Disorders Community.

Haemophilia : the official journal of the World Federation of Hemophilia·2026
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Diagnosis of bleeding disorder of unknown cause: how many tests are enough to diagnose BDUC?

Hematology. American Society of Hematology. Education Program·2025
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Determining the Impact of Combination Oral Contraceptives on Von Willebrand Factor and Factor VIII in Healthy Patients and Patients With Von Willebrand Disease: A Scoping Review and Meta-Analysis.

Haemophilia : the official journal of the World Federation of Hemophilia·2025
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Related Experiment Video

Updated: Nov 27, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Women and bleeding disorders: diagnostic challenges.

Paula D James1

  • 1Queen's University, Kingston, ON, Canada.

Hematology. American Society of Hematology. Education Program
|December 4, 2020
PubMed
Summary

Women with bleeding disorders experience significant gynecologic and obstetrical bleeding, often leading to delayed diagnosis. Improved diagnostic tools and clear nomenclature are crucial for better patient care and understanding of these conditions.

Area of Science:

  • Hematology
  • Women's Health

Background:

  • Women with bleeding disorders face numerous symptoms like bruising and oral bleeding.
  • Gynecologic and obstetrical bleeding are particularly severe in affected women.

Observation:

  • Many symptoms are misidentified as normal, leading to undiagnosed cases.
  • Lack of access to testing and unclear disease classification hinder diagnosis.

Findings:

  • Development of bleeding assessment tools and diagnostic strategies for von Willebrand disease (VWD) and platelet function disorders.
  • Initiatives to standardize nomenclature for hemophilia carriers are in progress.

Implications:

  • These advancements aim to improve the diagnosis and management of bleeding disorders in women.

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  • Standardized tools and clear communication are vital for effective patient care and research.