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Genomics of MPN progression.
Anand A Patel1, Olatoyosi Odenike1
1Section of Hematology/Oncology, Department of Medicine, The University of Chicago Medicine, Chicago, IL.
Hematology. American Society of Hematology. Education Program
|December 4, 2020
Summary
Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) involve genetic mutations driving disease progression. Understanding these genomic alterations is crucial for managing advanced MPNs and improving patient outcomes.
Area of Science:
- Hematology
- Genetics
- Oncology
Background:
- Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are stem cell disorders.
- These diseases feature activated JAK/STAT signaling.
- MPNs can progress to myelofibrosis or leukemia.
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