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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Identifying potential germline variants from sequencing hematopoietic malignancies.

Ira L Kraft1, Lucy A Godley1,2

  • 1Section of Hematology/Oncology, Department of Medicine and The University of Chicago Comprehensive Cancer Center and.

Hematology. American Society of Hematology. Education Program
|December 4, 2020
PubMed
Summary

Next-generation sequencing (NGS) helps identify genetic variants in blood cancers. This study presents criteria to distinguish patient germline variants from somatic ones, improving cancer risk assessment and patient care.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Next-generation sequencing (NGS) is crucial for managing hematological malignancies.
  • Distinguishing germline from somatic DNA alterations in tumor samples is challenging.

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