Related Experiment Video

Updated: Nov 27, 2025

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors
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Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors

Published on: October 17, 2025

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Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins

Caixia Hou1, Abhisek Mandal1, Jürgen Rohr1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

Structure (London, England : 1993)
|December 4, 2020
PubMed
Summary

Mithramycin (MTM) disrupts cancer-driving ERG and FLI1 proteins by binding DNA. Crystal structures reveal how MTM and its analogues interact with these factors, offering new therapeutic strategies for prostate cancer and Ewing sarcoma.

Keywords:
cancercrystal structurenatural productprotein-DNA bindingtranscription

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