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The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension
Warren L Wu1, Thales Papagiannakopoulos1
1Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Molecular Cell
|December 4, 2020
Abstract:
Takahashi et al. (2020) conduct a focused CRISPR/Cas9 screen against NRF2 target and other redox regulatory genes in both 2D- and 3D-culture systems, uncovering a vulnerability of spheroid cancer cells deprived of extracellular matrix to undergo ferroptosis.

