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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Nov 27, 2025

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Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology.

Camille R Simoneau1, Melanie Ott2

  • 1Gladstone Institute of Virology, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.

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The SARS-CoV-2 virus, causing COVID-19, affects multiple organs beyond the lungs. Stem cell models are crucial for studying direct infection

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Area of Science:

  • Virology and Cellular Biology
  • Infectious Diseases
  • Organoid Technology

Background:

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, leading to COVID-19, primarily impacts the respiratory system.
  • Emerging clinical evidence indicates that COVID-19 is a complex multi-organ disease with diverse complications.
  • Understanding the mechanisms of multi-organ dysfunction is critical for managing COVID-19.

Purpose of the Study:

  • To investigate the role of direct SARS-CoV-2 infection in multi-organ dysfunction.
  • To utilize advanced stem cell models for studying COVID-19 pathogenesis across different organ systems.
  • To elucidate the cellular and molecular basis of COVID-19's impact on organs like the lungs, gut, heart, and brain.

Main Methods:

  • Employing human stem cell-derived organoid models representing lung, gut, heart, and brain tissues.
  • Infecting these organoid models with SARS-CoV-2 to assess direct viral effects.
  • Analyzing cellular responses, viral replication, and tissue-specific damage in infected organoids.

Main Results:

  • Demonstrated that SARS-CoV-2 can directly infect stem cell-derived organoids from multiple organ systems.
  • Observed distinct patterns of cellular damage and dysfunction in lung, gut, heart, and brain organoids post-infection.
  • Provided in vitro evidence supporting the multi-organ tropism of SARS-CoV-2.

Conclusions:

  • Stem cell-derived organoid models are valuable tools for dissecting the multi-organ effects of SARS-CoV-2 infection.
  • Direct viral infection contributes significantly to the multi-organ pathology observed in COVID-19 patients.
  • Further research using these models can identify therapeutic targets for mitigating COVID-19 complications.