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Targeting Sirtuin 1 signaling pathway by ginsenosides.

Tingting Lou1, Qingxia Huang1, Hang Su2

  • 1Research Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China.

Journal of Ethnopharmacology
|December 4, 2020
PubMed
Summary

Ginsenosides, active compounds from ginseng, activate the Sirtuin 1 (SIRT1) pathway. This research highlights their potential in treating diseases like aging, inflammation, and cancer.

Keywords:
Energy metabolismGinsengGinsenosidesNAD(+)SIRT1

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Traditional Chinese Medicine

Background:

  • Ginseng, the "king of herbs," is a traditional Chinese medicine with numerous health benefits.
  • Ginsenosides are key active components of Panax ginseng, known for effects on memory, immunity, and aging.
  • These compounds are explored for their therapeutic potential in various diseases.

Purpose of the Study:

  • To review recent findings on ginsenosides targeting the Sirtuin 1 (SIRT1) signaling pathway.
  • To summarize the role of ginsenosides in disease prevention and treatment via SIRT1 modulation.

Main Methods:

  • Comprehensive literature search up to August 2020.
  • Databases searched include PubMed, ScienceDirect, Google Scholar, and China National Knowledge Infrastructure.
  • Keywords used were "SIRT1" combined with "ginseng" and "ginsenosides".

Main Results:

  • Sirtuin 1 (SIRT1) is a crucial NAD+-dependent enzyme involved in metabolism, oxidative stress, inflammation, and aging.
  • Most ginsenosides, particularly those with specific structures, act as SIRT1 activators.
  • Ginsenosides show potential in preventing and treating conditions such as oxidative stress, inflammation, aging, and tumorigenesis by targeting SIRT1.

Conclusions:

  • This review is the first to examine ginsenosides targeting SIRT1.
  • Findings offer new perspectives for preclinical and clinical research on ginsenosides for multiple disorders.
  • Ginsenosides represent a promising therapeutic strategy for various diseases through SIRT1 pathway modulation.