Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

7.0K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
7.0K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

7.8K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.8K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.0K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.0K
Chromatin Packaging02:21

Chromatin Packaging

9.1K
9.1K
Chromatin Packaging02:21

Chromatin Packaging

19.6K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
19.6K
Chromatin Packaging01:32

Chromatin Packaging

18.5K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
18.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation.

The EMBO journal·2026
Same author

Targeted CRISPR-Cas9 screening identifies core transcription factors controlling murine haemato-endothelial fate commitment.

Nature communications·2025
Same author

Engineered chromatin readers track damaged chromatin dynamics in live cells and animals.

Nature communications·2025
Same author

The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect.

Cancer research·2025
Same author

Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains.

Molecular cell·2024
Same author

Microbial Diversity of Soil in a Mediterranean Biodiversity Hotspot: Parque Nacional La Campana, Chile.

Microorganisms·2024

Related Experiment Video

Updated: Nov 27, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.7K

Regulatory mechanisms governing chromatin organization and function.

Rodrigo Villaseñor1, Tuncay Baubec1

  • 1Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Current Opinion in Cell Biology
|December 4, 2020
PubMed
Summary

Chromatin modifications on nucleosomes are crucial for genome regulation. This review explores advanced concepts like cooperativity and feedback loops in managing these essential epigenetic marks.

Keywords:
ChromatinDNA methylationEpigeneticsHistone modifications

More Related Videos

A Method to Study de novo Formation of Chromatin Domains
07:34

A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

5.6K
Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

4.1K

Related Experiment Videos

Last Updated: Nov 27, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.7K
A Method to Study de novo Formation of Chromatin Domains
07:34

A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

5.6K
Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

4.1K

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genetics

Background:

  • Nucleosomes package genetic material into chromatin.
  • Chemical modifications on nucleosomes act as interaction hubs for nuclear proteins.
  • These modifications are vital for DNA replication, transcription, and repair.

Purpose of the Study:

  • To review recent advances in understanding the regulation of chromatin modifications.
  • To discuss emerging concepts in chromatin biology.

Main Methods:

  • Literature review of established and emerging concepts in chromatin biology.
  • Discussion of regulatory mechanisms including cooperativity, multivalent interactions, feedback loops, and enzyme concentration.

Main Results:

  • Chromatin modification regulation involves complex, coordinated activities of writer, eraser, and reader enzymes.
  • Multicomponent regulatory circuits are essential for the spatiotemporal control of chromatin marks.
  • Emerging concepts like cooperativity and feedback loops offer new insights into regulation.

Conclusions:

  • Advances in chromatin biology have uncovered sophisticated mechanisms for regulating epigenetic marks.
  • Understanding these regulatory circuits is key to comprehending genome function and maintenance.
  • Future research directions include exploring cooperativity and enzyme concentration in chromatin regulation.