Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

592
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
592
Immunological Memory01:23

Immunological Memory

14.4K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.4K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

271
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
271
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.8K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

690
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
690

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Description and therapy of palmoplantar pustular psoriasis under IL-17A or dual IL-17A/F inhibition.

Journal of autoimmunity·2026
Same author

Combined immunosuppressive therapy in systemic sclerosis-associated interstitial lung disease: Phenotypes matter.

Autoimmunity reviews·2026
Same author

Real-world clinical experience with upadacitinib in a cohort of Italian patients with axial spondyloarthritis.

Frontiers in pharmacology·2026
Same author

Modulation of proinflammatory but not regulatory cytokines by in vitro JAK inhibition in peripheral blood B-cells of patients with psoriatic arthritis.

Journal of dermatological science·2026
Same author

Achievement and Maintenance of Remission with Upadacitinib in Patients with Moderate-to-Severe Rheumatoid Arthritis in Italy: 1-Year Data from UPHOLD, a Prospective Real-World Observational Study.

Rheumatology and therapy·2026
Same author

Natural language processing to intercept rheumatoid and psoriatic arthritis from clinical notes in the Emergency Department.

Therapeutic advances in musculoskeletal disease·2026
Same journal

MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity.

Journal of autoimmunity·2026
Same journal

Neonatal total parenteral nutrition and the risk of childhood autoimmune diseases: A nationwide population-based study of 2.3 million children.

Journal of autoimmunity·2026
Same journal

Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes.

Journal of autoimmunity·2026
Same journal

Intermittent fasting ameliorates Sjögren's syndrome-related dry eye through a preponderant bile acid-Akkermansia homeostasis establishment.

Journal of autoimmunity·2026
Same journal

High-intensity immunosuppression versus modern standard care in poor-prognosis diffuse cutaneous systemic sclerosis: A propensity-matched study.

Journal of autoimmunity·2026
Same journal

Efficacy, safety, and tolerability of treatments for interstitial lung disease associated with rtoid arthritis: A systematic review and network meta-analysis.

Journal of autoimmunity·2026
See all related articles

Related Experiment Video

Updated: Nov 27, 2025

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

2.2K

Mushrooms and immunity.

Francesca Motta1, M Eric Gershwin2, Carlo Selmi1

  • 1Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Journal of Autoimmunity
|December 4, 2020
PubMed
Summary
This summary is machine-generated.

Mushroom compounds like glucans and proteins show promise for immunity and cancer treatment, but more rigorous human studies are needed due to variability in research. Further investigation into bioactive mushroom compounds is essential for health applications.

Keywords:
CytokinesGlucansImmunityLeukocytesMushroomsNutraceutical

More Related Videos

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.6K
Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System
07:21

Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System

Published on: October 20, 2023

1.7K

Related Experiment Videos

Last Updated: Nov 27, 2025

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

2.2K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.6K
Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System
07:21

Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System

Published on: October 20, 2023

1.7K

Area of Science:

  • Mycology
  • Immunology
  • Pharmacology

Background:

  • Mushrooms have a long history in traditional medicine, with recent scientific interest focusing on their bioactive compounds.
  • Glucans and proteins are key mushroom components with demonstrated immunomodulatory and anti-tumor properties.
  • Other bioactive compounds include lipids (cholesterol reduction) and phenols (antioxidant effects).

Purpose of the Study:

  • To comprehensively review and critically discuss the biochemical changes induced by mushroom compounds.
  • To compare in vitro findings with in vivo and human studies on mushroom bioactives.
  • To highlight the need for standardization and rigorous research in mushroom nutraceuticals.

Main Methods:

  • Review of existing scientific literature on mushroom compounds and their biological effects.
  • Analysis of in vitro studies on immune cells (macrophages, dendritic cells, T cells, NK cells).
  • Comparison of in vitro data with findings from animal models and human clinical trials.

Main Results:

  • Mushroom-derived glucans and proteins are primary drivers of immunomodulatory and anti-tumor effects.
  • In vitro studies show significant biochemical changes in immune cells, but clinical evidence is limited.
  • Variability in mushroom strains, cultivation, and extraction methods complicates direct comparisons and clinical application.

Conclusions:

  • While promising, current evidence from human studies is insufficient to support the use of mushroom extracts for treating diseases.
  • Standardization of mushroom products and rigorous clinical trials are crucial for validating their health benefits.
  • Compounds like lentinan show potential in cancer therapy, warranting further research.