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Multiplexed Nanobiosensors: Current Trends in Early Diagnostics.

Greta Jarockyte1,2, Vitalijus Karabanovas1,2, Ricardas Rotomskis2

  • 1Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu 5, LT-08406 Vilnius, Lithuania.

Sensors (Basel, Switzerland)
|December 5, 2020
PubMed
Summary

Scientists are developing advanced nanomaterial-based biosensors for multiplexed biomarker detection. These tools promise faster, cheaper, and more reliable diagnostics for personalized medicine and early disease identification.

Keywords:
gold nanoparticlesmultiplexingnanoparticlesquantum dotssilver nanoparticlesupconverting nanoparticles

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Personalized medicine requires rapid, cost-effective diagnostic tools for biomarker detection.
  • Multiplexing, the simultaneous detection of multiple analytes, enhances diagnostic accuracy and enables early disease identification.
  • Nanomaterial-based biosensors offer promising platforms for advanced multiplexed biomarker analysis.

Purpose of the Study:

  • To review the progress and applications of various nanoparticles in multiplexed biomarker detection.
  • To highlight emerging nanomaterials beyond quantum dots for multiplexing.

Main Methods:

  • Review of current literature on nanoparticle-based biosensors for multiplexing.
  • Focus on quantum dots, gold, silver, and rare earth metal nanoparticles.
  • Analysis of optical properties and applications in biomarker quantification.

Main Results:

  • Quantum dots are established photoluminescent nanoparticles for multiplexing.
  • Gold, silver, and rare earth metal nanoparticles present emerging opportunities due to unique optical properties.
  • Nanoparticle applications are advancing for simultaneous detection of multiple clinical biomarkers.

Conclusions:

  • Nanoparticle-based biosensors are crucial for developing next-generation diagnostic tools.
  • Emerging nanomaterials offer enhanced capabilities for multiplexed biomarker detection.
  • Continued research in this area will drive innovation in personalized medicine and early disease diagnosis.