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Urine High-Sensitivity Troponin I Predict Incident Cardiovascular Events in Patients with Diabetes Mellitus

Ju-Yi Chen1, Shuenn-Yuh Lee2, Yi-Heng Li1

  • 1Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

Journal of Clinical Medicine
|December 5, 2020
PubMed

Insights

Urinary high-sensitivity troponin I (hs-TnI) can predict cardiovascular events in diabetes mellitus patients. This non-invasive biomarker offers a promising tool for early risk assessment in diabetic individuals.

Area of Science:

  • Cardiology
  • Diabetology
  • Biomarker Research

Background:

  • Cardiovascular (CV) events significantly worsen outcomes for patients with diabetes mellitus (DM).
  • Serum high-sensitivity troponin I (hs-TnI) is established for acute coronary syndrome but its utility in urine for DM patients is under-researched.
  • Predicting incident CV events in DM requires accessible and reliable biomarkers.

Purpose of the Study:

  • To investigate the accuracy of urine hs-TnI as a predictor of incident CV events in patients with DM.
  • To establish the diagnostic and prognostic value of urinary hs-TnI in a diabetic cohort.
  • To determine an optimal cutoff value for urine hs-TnI for CV event prediction.

Main Methods:

  • Prospective study involving 378 patients with DM.
  • Measurement of fresh urine hs-TnI levels.
  • Follow-up for incident CV events over 3 months using medical records.

Main Results:

  • Significantly higher urine hs-TnI levels were observed in patients who experienced subsequent CV events.
  • Multivariate logistic regression identified urine hs-TnI > 4.10 pg/mL as an independent predictor of incident CV events.
  • ROC-AUC analysis indicated an optimal cutoff of 1.55 pg/mL for urine hs-TnI, with an area of 0.611 (p=0.027).

Conclusions:

  • Urinary hs-TnI is a potential non-invasive biomarker for predicting incident CV events in patients with DM.
  • A single urine hs-TnI measurement may be a convenient and acceptable method for CV risk assessment in this population.
  • Further research can validate urine hs-TnI for routine clinical use in managing diabetic cardiovascular risk.

Keywords:
diabetes mellitusincident cardiovascular eventstroponinurine

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