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Updated: Nov 27, 2025

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
Published on: January 13, 2022
Active proportional electromyogram controlled functional electrical stimulation system
Bethel A C Osuagwu1, Emily Whicher2, Rebecca Shirley3
1National Spinal Injuries Centre, Stoke Mandeville Hospital, Mandeville Road, Aylesbury, HP21 8AL, UK. bethel.osuagwu@gmail.com.
This study introduces an adaptive filtering software to extract electromyogram (EMG) signals during functional electrical stimulation (FES) for neurorehabilitation. The system successfully modulated FES intensity based on intended movement in patients with tetraplegia.
Area of Science:
- Biomedical Engineering
- Neurorehabilitation
- Assistive Technology
Background:
- Intention-driven functional electrical stimulation (FES) shows promise for motor neurorehabilitation.
- Proportional control of FES using voluntary electromyogram (EMG) is a key goal.
- Electrical artefact contamination during FES hinders EMG signal extraction and real-time application.
Purpose of the Study:
- To develop a software-based solution for real-time extraction of voluntary EMG signals during FES.
- To overcome limitations of previous methods, including poor signal extraction, hardware dependency, and unsuitability for online use.
- To validate an adaptive filtering technique for EMG-FES systems in neurorehabilitation.
Main Methods:
- An entirely software-based adaptive filtering technique with an optional comb filter was implemented.
- The system extracts voluntary EMG signals from muscles under FES in real-time.
- The developed Active FES system was validated in a cohort of fifteen patients with tetraplegia.
Main Results:
- The implemented technique successfully extracted voluntary EMG signals, demonstrating coherence with noise-free versions.
- Unlike classic comb filters, the adaptive approach provided superior signal quality.
- The Active FES system effectively modulated FES intensity proportionally to intentional movement in patients.
Conclusions:
- The developed software-based Active FES system provides a viable solution for real-time EMG signal extraction during FES.
- This advancement has significant implications for improving motor neurorehabilitation and developing advanced assistive technologies.
- The system's success in patients with tetraplegia highlights its potential for restoring motor function.
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