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Fetal teratogenicity in a rhesus macaque (Macaca mulatta): Association with the chronic maternal treatment of

Carissa E Hunter1, Rachelle L Stammen2, Terell Hamlet1

  • 1Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

Journal of Medical Primatology
|December 5, 2020
PubMed

Amitriptyline is a tricyclic antidepressant commonly prescribed in humans for pain and sleep disorders and in non-human primates for self-injurious behaviors. Here, we report a clinical case on the teratogenic effect of maternal-fetal amitriptyline exposure.

Keywords:
amitriptylinenon-human primatesself-injurious behaviortricyclic antidepressant

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Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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