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Osteitis in Systemic Sclerosis: A Nationwide Case-Control Retrospective Study.
Cyril Cosse1, Solen Kernéis2, Alain Lescoat3
1Service de Médecine Interne, Centre de Référence Maladies Systémiques Auto-Immunes Rares d'Ile de France, Hôpital Cochin, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Paris, France.
Systemic sclerosis patients with osteitis often experience pain and swelling, frequently linked to digital tip ulcers. Treatment involves antibiotics like fluoroquinolones, but sequelae are common.
Area of Science:
- Rheumatology
- Infectious Disease
- Radiology
Background:
- Systemic sclerosis (SSc) is an autoimmune disease with limited data on osteitis.
- Osteitis in SSc presents diagnostic and management challenges.
Purpose of the Study:
- To describe and characterize osteitis in Systemic Sclerosis patients.
- To identify factors associated with osteitis in SSc.
Main Methods:
- Nationwide, multicenter, retrospective, case-control study.
- Included SSc patients with osteitis diagnosis.
- Utilized radiography, CT, and MRI for diagnosis.
Main Results:
- 48 SSc patients with osteitis were analyzed.
- Digital tip ulcers were present in 54.1% of cases.
- Common pathogens included Staphylococcus aureus, anaerobes, and Enterobacteriaceae.
- High rates of functional sequelae (32%) and recurrence (12.6%) were observed.
Conclusions:
- Digital tip ulcers are a significant associated factor for osteitis in SSc.
- Osteitis in SSc can lead to substantial functional sequelae.
- First-line antibiotic therapy includes fluoroquinolones or amoxicillin/β-lactamase inhibitor.
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