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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Updated: Nov 27, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Cell-based immunotherapy in gynecologic malignancies.

Kalika Kamat1, Venkatesh Krishnan, Jonathan S Berek

  • 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Women's Cancer Center, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.

Current Opinion in Obstetrics & Gynecology
|December 5, 2020
PubMed
Summary
This summary is machine-generated.

Cell-based immunotherapies show promise for gynecological cancers. Current trials indicate safety and tolerability, with novel innate immune cell approaches under investigation.

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Area of Science:

  • Oncology
  • Immunology
  • Gynecologic Oncology

Background:

  • Cell-based immunotherapies are emerging as a significant treatment modality for solid tumors.
  • Gynecological cancers represent a critical area for the application of these innovative therapies.

Purpose of the Study:

  • To review the current landscape of cell-based immunotherapies in solid tumors, with a specific focus on gynecological malignancies.
  • To provide an update on recent advancements and clinical trial outcomes in this field.

Main Methods:

  • Review of recent clinical trial data and ongoing research in cell-based immunotherapies for gynecological cancers.
  • Inclusion of novel approaches targeting both innate and adaptive immune cells.

Main Results:

  • Early-phase clinical trials demonstrate favorable safety and tolerability profiles for various cell therapies in gynecological cancers.
  • Emerging strategies, including the use of innate immune system cells, are currently being evaluated in Phase I trials.

Conclusions:

  • Cell-based therapies are increasingly being investigated in clinical trials for gynecological cancers, utilizing both innate and adaptive immune cells.
  • The majority of these therapeutic strategies are well-tolerated and exhibit promising outcomes in initial studies, warranting further investigation.