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Updated: Nov 27, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
Published on: March 25, 2016
Coronavirus Disease 2019 (COVID-19)-Related Multisystem Inflammatory Syndrome in a Pregnant Woman
Moti Gulersen1, Cara Staszewski, Evelina Grayver
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, the Department of Cardiology, the Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, and the Department of Anesthesiology, North Shore University Hospital-Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.
Background:
Recent reports have described a rare but severe complication of coronavirus disease 2019 (COVID-19) in nonpregnant adults that is associated with extrapulmonary organ dysfunction and appears to be secondary to a hyperinflammatory state.
Case:
A multiparous woman at 28 weeks of gestation, diagnosed with COVID-19 4 weeks prior, was admitted with chest pain. Evaluation indicated myocarditis and marked elevations of inflammatory markers consistent with multisystem inflammatory syndrome in adults. The patient developed cardiogenic shock and required mechanical ventilation. Treatment with intravenous immunoglobulin and high-dose corticosteroids was associated with a favorable maternal and fetal outcome.
Conclusion:
Multisystem inflammatory syndrome in adults associated with COVID-19 in pregnancy is a critical illness, presenting several weeks after initial infection. Treatment with intravenous immunoglobin and corticosteroids was associated with a favorable outcome.
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