Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

18.9K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
18.9K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

2.6K
2.6K
Protein Organization01:24

Protein Organization

8.5K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
8.5K
Protein Organization01:13

Protein Organization

153.2K
Overview
153.2K
Protein Networks02:26

Protein Networks

4.3K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.3K
Protein Networks02:26

Protein Networks

2.6K
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrinsically disordered proteins and liquid-liquid phase separation in SARS-CoV-2 interactomes.

Journal of cellular biochemistry·2023
Same author

IsoProt: A Complete and Reproducible Workflow To Analyze iTRAQ/TMT Experiments.

Journal of proteome research·2019
Same author

Structural disorder of plasmid-encoded proteins in Bacteria and Archaea.

BMC bioinformatics·2018
Same author

Intrinsic disorder here, there, and everywhere, and nowhere to escape from it.

Cellular and molecular life sciences : CMLS·2017
Same author

Comprehensive review of methods for prediction of intrinsic disorder and its molecular functions.

Cellular and molecular life sciences : CMLS·2017
Same author

Virucidal activity of cell-penetrating peptides of viral origin.

Journal of biomolecular structure & dynamics·2017

Related Experiment Video

Updated: Nov 27, 2025

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.4K

Bioinformatics analysis of correlation between protein function and intrinsic disorder.

Goran Vinterhalter1, Jovana J Kovačević2, Vladimir N Uversky3

  • 1Agilent Technologies Belgium NV, De Kleetlaan 5/bus 9, 1831 Diegem, Belgium.

International Journal of Biological Macromolecules
|December 5, 2020
PubMed
Summary

This study explores protein intrinsic disorder and molecular function using Gene Ontology (GO) terms. Results show a strong correlation between protein disorder and specific GO terms, offering new insights into protein function.

Keywords:
Intrinsic disorderJaccard indexProtein function

More Related Videos

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses
05:13

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses

Published on: January 12, 2024

1.3K
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.5K

Related Experiment Videos

Last Updated: Nov 27, 2025

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.4K
Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses
05:13

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses

Published on: January 12, 2024

1.3K
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.5K

Area of Science:

  • Proteomics
  • Bioinformatics
  • Structural Biology

Background:

  • Understanding the link between protein intrinsic disorder and molecular function is crucial for deciphering protein behavior.
  • Previous studies analyzed this correlation using Swiss-Prot keywords, prompting further investigation with more comprehensive functional annotations.

Purpose of the Study:

  • To investigate the correlation between protein intrinsic disorder and molecular function using the CAFA3 dataset with Gene Ontology (GO) terms.
  • To compare findings with a previous study that used Swiss-Prot keywords.
  • To develop a novel method for mapping Swiss-Prot keywords to GO terms.

Main Methods:

  • Utilized the CAFA3 challenge training dataset, annotating over 66,000 proteins with GO terms.
  • Employed the PONDR VSL2b predictor to classify proteins as intrinsically disordered or ordered.
  • Associated GO terms with Swiss-Prot function keywords and analyzed correlations.

Main Results:

  • Identified significant numbers of both order-related and disorder-related Swiss-Prot keywords and GO terms.
  • Found 746 GO terms to be highly order-related and 564 highly disorder-related.
  • Observed consistent results between GO terms and Swiss-Prot keywords when mappings were possible, with a prevalence of disorder-related binding functions in the current dataset.

Conclusions:

  • Protein intrinsic disorder is strongly correlated with specific molecular functions, particularly binding functions.
  • The study highlights the utility of GO terms for a more detailed analysis of protein function-disorder relationships.
  • A new method for mapping Swiss-Prot keywords to GO terms was proposed, enhancing functional annotation comparisons.