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Prognostic value of Goldberger's electrocardiographic criteria for left ventricular dysfunction
Kang Rui Xiang1, Elsayed Z Soliman2, Prashant D Bhave3
1Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Journal of Electrocardiology
|December 5, 2020
Summary
The Goldberger electrocardiogram (ECG) triad, known for detecting left ventricular dysfunction (LVD), also predicts increased risk of all-cause and cardiovascular mortality in the general population.
Area of Science:
- Cardiology
- Electrocardiography
- Public Health
Background:
- The Goldberger electrocardiographic (ECG) triad is established for detecting left ventricular dysfunction (LVD).
- Its prognostic significance for predicting poor outcomes remains unknown.
Purpose of the Study:
- To investigate the association between the Goldberger ECG-LVD triad and mortality in the general population.
- To determine if the triad predicts all-cause and cardiovascular mortality.
Main Methods:
- Analysis of 8426 participants from the Third National Health and Nutrition Examination Survey.
- Defined Goldberger ECG-LVD triad criteria: high precordial QRS voltage, low limb lead QRS voltage, and poor R wave progression.
- Ascertained mortality using the National Death Index over a median follow-up of 13.8 years.
Main Results:
- At least one Goldberger triad criterion was present in 47.3% of participants at baseline.
- The presence of at least one criterion was associated with a significantly increased risk of all-cause mortality (HR 1.17) and cardiovascular mortality (HR 1.19).
- These associations remained significant after multivariable adjustment.
Conclusions:
- The Goldberger ECG-LVD triad demonstrates prognostic value beyond its diagnostic utility for LVD.
- The triad can serve as a predictor of adverse outcomes, including mortality, in the general population.
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