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The potential role of Bi-specific antibodies in acute myeloid leukemia

Musa Yilmaz1, Farhad Ravandi1

  • 1The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX, USA.

Best Practice & Research. Clinical Haematology
|December 6, 2020
PubMed

Bispecific antibodies consist of antigen recognition sites from two or more antibodies redirecting effector immune cell against target on tumor cells. Rapidly evolving medical technologies enabled engineering and development of recombinant protein products, and this, combined with interest from the pharmaceutical industry, further advanced the bispecific antibody research. Over 50 different types of bispecific antibody constructs are now being manufactured and explored in ongoing or future clinical trials. In this review, we will summarize the available data for bispecific antibodies developed and being investigated for the treatment of patients with acute myeloid leukemia.

Keywords:
AMLBiKEBiTEBispecific antibodyDARTImmunotherapyTandem antibodyTriKE

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