¹⁸F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology

In mouse models of dengue virus (DENV) infection, ¹⁸F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of ¹⁸F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the ¹⁸F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that ¹⁸F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for ¹⁸F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.