RIFM fragrance ingredient safety assessment, methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate, CAS Registry...

Area of Science:

• Chemical safety assessment
• Toxicology
• Environmental risk assessment

Background:

• Methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate is a chemical compound used in various applications.
• A comprehensive safety evaluation is necessary to ensure its safe use and minimize potential risks.

Purpose of the Study:

• To assess the safety of Methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate for human health and the environment.
• To evaluate endpoints including genotoxicity, repeated dose toxicity, reproductive toxicity, and local respiratory toxicity.
• To determine phototoxicity/photoallergenicity, skin sensitization potential, and environmental safety.

Main Methods:

• Genotoxicity assays were performed.
• Repeated dose toxicity was evaluated by calculating the Margin of Exposure (MOE).
• Reproductive and local respiratory toxicity were assessed using the Threshold of Toxicological Concern (TTC).
• Phototoxicity/photoallergenicity was predicted using ultraviolet (UV) spectra.
• Skin sensitization was evaluated based on current usage levels.
• Environmental safety was assessed using International Fragrance Association (IFRA) standards and risk quotients (PEC/PNEC).

Main Results:

• Methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate demonstrated no genotoxicity.
• A calculated MOE >100 confirmed safety for repeated dose toxicity.
• Exposure levels were below the TTC for reproductive and local respiratory toxicity.
• No safety concerns were identified for skin sensitization.
• The compound is not expected to be phototoxic or photoallergenic.
• Methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate is not Persistent, Bioaccumulative, and Toxic (PBT), with risk quotients <1.

Conclusions:

• The existing data support the safe use of Methyl-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylate as described.
• No significant safety concerns were identified across all evaluated toxicological and environmental endpoints.
• The safety assessment confirms the compound's suitability for its intended applications under current usage conditions.