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Peptide-functionalized delivery vehicles for enhanced cancer therapy
Si-Yue Tang1, Hua Wei1, Cui-Yun Yu1
1Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
International Journal of Pharmaceutics
|December 6, 2020
Summary
Peptide-functionalized delivery systems enhance cancer therapy by incorporating specific peptides. This review details conjugation chemistry and categorizes peptides for improved therapeutic efficiency.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Drug Delivery Systems
Background:
- Functional peptides offer specific biological recognition and cell penetration for biomedical applications.
- Tailor-made peptide sequences integrated into delivery systems enhance therapeutic efficiency for malignant diseases.
Purpose of the Study:
- To review recent advancements in peptide-functionalized delivery vehicles for enhanced cancer therapy.
- To emphasize the chemistry of peptide conjugation in these systems.
Main Methods:
- Summarized primary synthetic strategies for peptide conjugation.
- Classified four types of peptide-functionalized delivery vehicles based on peptide function: tumor-targeting, cell-penetrating, subcellular organelle-targeting, and tumor-penetrating peptides.
Main Results:
- Detailed the chemistry adopted for peptide conjugation.
- Presented a classification of peptide-functionalized delivery vehicles by peptide function.
Conclusions:
- Peptide-functionalized delivery platforms offer a robust strategy for enhanced cancer therapy.
- Guidelines for designing peptides, screening conjugation strategies, and optimizing peptide properties are provided for future development.
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