Shedding light on learning and memory: optical interrogation of the synaptic circuitry

In the quest for the physical substrate of learning and memory, a consensus gradually emerges that memory traces are stored in specific neuronal populations and the synaptic circuits that connect them. In this review, we discuss recent progresses in understanding the reorganization of synaptic circuits and neuronal assemblies associated with learning and memory, with an emphasis on optical techniques for in vivo interrogations. We also highlight some open questions on the missing link between synaptic modifications and neuronal coding, and how stable memory persists despite synaptic and neuronal fluctuations.